Our main goal in the project is to select aptamers against the receptor Tas1R3, a biomarker for Non-Small Cell Lung Cancer (NSCLC). APTUS is going to characterize the affinity and specificity of the selected aptamers against the target protein. Finally, Tas1R3-aptamers are going to decorate Sphingomyelin nanoemulsions to improve the interaction of the nanoparticles with metastatic cancer cells, for detection and specific treatment of occult micrometastases and improve cancer survival.